LONGEVITY with Nathalie Niddam

Aimie Apigian, an innovative leader in the biology of trauma, whose work bridges the worlds of science, medicine, and lived experience. In our conversation, Dr. Apigian opens up about her journey from conventional medicine—where symptom management was the norm—to uncovering the physiological roots of trauma and the crucial role our nervous system plays in resilience and healing. She shares how her own health struggles, her work with adopted children, and a relentless curiosity led her to re-examine everything she thought she knew about stress, autoimmunity, and capacity. The 7-Day Somatic Healing for Stored Emotions - https://traumahealingaccelerated.mykajabi.com/a/2148170319/wdrhGYaY 21-Day Journey, a daily live session program that helps participants understand how much trauma their body may be holding - https://traumahealingaccelerated.mykajabi.com/a/2147704575/wdrhGYaY Episode Timestamps: Introduction, host's mission, and episode theme... 00:00:00 Science behind trauma, limits of traditional medicine, and autoimmune experiences... 00:06:11 Attachment, symptom management, functional medicine, and healing journey... 00:08:17 Mold exposure, state triggers, brain inflammation, and capacity blocks... 00:14:22 Medical gaslighting, trauma validation, and biological capacity... 00:18:25 Safety, resilience, and chronic survival state effects... 00:19:32 Misconceptions about chronic stress—emergency brake and vagus nerve... 00:22:27 Attachment patterns, autoimmunity, and shrinking world... 00:28:47 Chronic survival loop, exhaustion, coping strategies, and shutdown... 00:31:11 Moving to repair: phases of healing and gentle approaches... 00:34:08 Somatic practices, art therapy, and different expressions of trauma... 00:39:01 Shifts in sleep, digestion, anxiety, and felt safety... 00:42:06 Tracking nervous system state: strategies and awareness... 00:46:41 Therapy limitations: biology and somatic integration... 00:48:42 Retraining vs. managing symptoms, stabilization, and healing... 00:54:53 Capacity, resilience, lessons from centenarians, and longevity... 01:00:06 Trauma's impact on mitochondria, telomeres, and generational health... 01:06:27 Gut microbiome and trauma: two-way connection... 01:08:03 Our Amazing Sponsors: Manukora Honey - rich, creamy Manuka honey packed with powerful bioactives, all in just one heaped teaspoon a day. Go to MANUKORA.com/NAT to save up to 31% plus $25 in free gifts with the Starter Kit. Mitopure Longevity Gummies by Timeline — Clinically backed Urolithin A supports mitochondrial health to boost energy, recovery, and healthy aging, all in an easy daily gummy instead of another pill; go to timeline.com/nat20 for 20% off Mitopure Gummies. Ozlo - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to ozlosleep.com/nat and use code NAT to get $75 off. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

Today, I'm joined by the inspiring Leslie Kenny, Oxford-based longevity expert and a living example of turning adversity into vitality. After being told at 39 that she had lupus, rheumatoid arthritis, and just five years to live, Leslie defiantly forged a new path—reversing her diagnoses, restoring her thyroid health, and even welcoming a healthy baby girl at 43. Her story is a testament to the power of questioning the status quo, honoring the wisdom within our bodies, and refusing to accept decline as inevitable. Leslie has a generous offer for you, when you visit oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout you'll get 20% off. Episode Timestamps: Welcome, show intro, and overview... 00:00:00 Leslie Kenny's health journey and reversing disease... 00:00:30 Biological vs. chronological age and the immune system... 00:04:55 Impact of trauma and stress on aging... 00:11:51 Overcoming prognosis: lifestyle and scientific interventions... 00:18:02 Diet, tracking, and removing triggers... 00:22:21 The overlooked importance of thyroid health... 00:32:23 Dangers of overdoing fasting and hormesis... 00:40:21 Autophagy basics and the cellular cleanup crew... 00:44:06 Spermidine's role, sourcing, and supplement quality... 01:10:19 Optimizing longevity habits and daily routines... 01:29:44 Our Amazing Sponsors: Tro Zzz by Troscriptions – A fast-acting sleep troche that dissolves in your cheek and combines melatonin with compounds like honokiol, adenosine, cordycepin, CBD, CBN, and 5-HTP to support deep, restorative sleep when travel, stress, or late workouts throw things off. Head to troscriptions.com and use code NAT10 for 10% off your first order. BEAM Minerals - Low energy often starts in the mitochondria. Nature's Marvels Bioregulators - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to http://www.profound-health.com/?Aff=Longevity15 and use code NAT15 for 15% off your first order. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

Natalie Yivgi-Ohana, a pioneering scientist whose passion for mitochondria unlocks new frontiers in longevity medicine. Our conversation truly blew my mind—Dr. Yivgi-Ohana brings decades of expertise to demystify these tiny, ancient powerhouses that fuel every cell in our bodies, impact our hormones, drive immunity, and, as it turns out, play a central role in how we age. Episode Timestamps: Welcome to the Longevity Podcast and today's focus on mitochondria... 00:00:00 Maternal inheritance and critical functions of mitochondria... 00:05:56 Mitochondria as energy producers and hormone regulators... 00:07:03 Aha moments: mitochondria control life, death, and disease... 00:08:55 Endosymbiotic theory: how mitochondria originated... 00:10:19 Chronic disease, aging, and the connection to mitochondria... 00:16:10 Substrate fuels: carbs, fats, and importance of metabolic flexibility... 00:20:18 Mitochondria's control over immune system and signaling... 00:26:39 Mitochondrial transfer: how cells share organelle "powerhouses"... 00:32:42 Groundbreaking therapy: transplanting mitochondria for rare diseases... 00:36:40 Expanding mitochondrial therapies to age-related diseases... 00:42:57 Aging in women: hormones, mitochondria, and inflection points... 00:51:00 Stem cell exhaustion and cellular renewal... 00:52:24 Biomarkers: ways to measure mitochondrial health... 01:03:11 Supplements, lifestyle, and emotional health for mitochondria... 01:15:47 Medication choices and minimizing mitochondrial toxicity... 01:24:04 Our Amazing Sponsors: O₃RACLE by Wizard Sciences — A daily ozonated oil capsule designed to support immune balance, cellular communication, and antioxidant production without clinics, machines, or complicated routines; learn more at wizardsciences.com and use code NAT15 for 15% off. Magnesium Breakthrough by BIOptimizers — A full-spectrum magnesium supplement combining seven highly absorbable forms to support sleep, stress, muscle recovery, and nervous system balance in one nightly habit. Save 15% at bioptimizers.com/bionat with code BIONAT Vitali - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

Today, I'm joined by the insightful Courtney Van Bussum, a biomedical engineer and entrepreneur who has become a rising force in longevity science. Courtney shares how growing up in a family of healthcare innovators shaped her journey, and how she pivoted from startup life to tackling age-related challenges—especially when COVID brought her back to her roots and reignited her passion for cellular health. If you want to try Endotelio 1-MNA and save 10% click here and code NAT10 will be entered for you at checkout. Episode Timestamps: Welcome and introduction to Longevity Podcast... 00:00:00 Challenging beliefs about aging and cellular health... 00:12:00 Deep dive into NAD+ biochemistry and cellular function... 00:13:08 NAD+/NADH balance: Why both matter... 00:15:24 Why NAD+ declines: Not just aging, but increased degradation...00:18:26 The role of CD38 and NMNT enzymes in NAD metabolism... 00:20:14 Controversy and confusion: NAD+ precursors (NR, NMN) and IVs... 00:22:28 Methylation's hidden importance in NAD supplementation... 00:30:55 Supplementing 1-MNA: Understanding dosages and applications... 00:50:54 Assessing NAD+ status: Biomarkers and limitations of testing... 00:53:01 Lifestyle ROI: Sleep, exercise, and circadian rhythm for NAD preservation... 00:57:14 Ketones: Beyond performance, supporting cellular energy and longevity... 01:06:03 Future of NAD science: Anticipating new insights and risks... 01:11:45 Confidence and humility: Advice for navigating the longevity field... 01:18:52 Our Amazing Sponsors: Qualia Creatine+ by Qualia Life – A clinically formulated blend of two highly bioavailable forms of creatine plus magnesium and electrolytes to support lean muscle, cellular energy, and brain health—especially for women over 40 who naturally produce less with age. Go to qualialife.com/nathalie and use code NATHALIE to save up to 50%, plus an additional 15% off. Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset after the holidays without suffering. Go to lvluphealth.com and use code NAT for 20% off. Gut Essentials Bundle by Just Thrive Health – This powerhouse duo pairs the only probiotic clinically proven to arrive 100% alive in your gut with science-backed Digestive Bitters to reduce bloat, curb cravings, and support better energy fast. Take the Just Thrive Feel Better Challenge and save 20% at justthrivehealth.com/NAT20 with code NAT20. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

Cynthia Keller, a pediatrician whose passion for integrative and functional medicine has reshaped how we understand post-COVID health challenges. Dr. Keller opens up about her journey from conventional medicine to designing unique solutions for children and families, revealing how her care, presence, and determination to "solve the unsolvable" led to breakthroughs in treating mood changes, weight gain, and energy loss after COVID. Special Offer: If you go to alchemicmedicinals.com and use code NatRocks at checkout, you'll get a whopping 50% off of the Tryptophan Re-Genesis™ Powder while supplies last! (Capsules not included). Episode Timestamps: Introduction and host's mission... 00:00:00 From standard care to integrative pediatrics... 00:05:05 Patterns in pediatric development and disease... 00:09:19 Gut health, emotional factors, and parenting... 00:10:44 Clinic model and multidisciplinary care... 00:15:04 Post-COVID nutrient depletion: clinical discoveries... 00:18:03 Key depleted cofactors and rapid recovery... 00:19:31 COVID's ongoing impact on gut and microbiome... 00:24:39 Grassroots collaboration and evolving strategies... 00:26:28 Clinical patterns: mood, weight, thirst... 00:36:02 Family-wide interventions and quick results... 00:46:24 Symptoms-based approach, minimal testing... 00:52:07 Supplementation protocol and cautions... 00:57:14 Product development and access... 01:08:22 Infant microbiome and generational shifts... 01:10:28 Pediatricians: importance of listening and presence... 01:20:09 Love and connection in clinical care... 01:21:01 Modern dysregulation: loss of boredom... 01:22:28 Our Amazing Sponsors: Ozlo - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to ozlosleep.com/nat and use code NAT to get $75 off. Youth Daily by Young Goose — An all-in-one moisturizer powered by NAD+ nano precursors to boost elasticity, smooth wrinkles, and keep your skin looking fresh, dewy, and full of life; grab yours at younggoose.com and use code Nat10 for first orders or this link and code 5NAT for returning customers. Mitopure Longevity Gummies by Timeline — Clinically backed Urolithin A supports mitochondrial health to boost energy, recovery, and healthy aging, all in an easy daily gummy instead of another pill; go to timeline.com/nat20 for 20% off Mitopure Gummies. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

Today, I'm joined by the remarkable Cathy Eason, whose work in the nitric oxide and vascular health space is changing the conversation around resilience and heart health for midlife women. Cathy dives into why cardiovascular disease is still the number one threat to women globally, and how the drop in estrogen during menopause impacts nitric oxide production—an overlooked factor that quietly influences everything from energy to cognition. Episode Timestamps: Podcast welcome and cardiovascular focus... 00:00:00 Introducing Cathy Eason, nitric oxide updates... 00:03:26 Menopause as a vascular event... 00:08:50 Everyday signs of cardiovascular decline... 00:11:19 Body awareness and tracking health metrics... 00:14:15 Healthy labs but low resilience... 00:16:56 Defining and understanding menopause... 00:22:48 Systems affected during menopause... 00:25:26 Nitric oxide's critical role... 00:44:24 Testing and optimizing blood flow... 00:48:14 Value of health patterns over labs... 00:55:09 Communicating health trends to providers... 00:56:32 Berkeley Life supplement recommendation... 00:59:02 Prioritizing basic health habits... 01:01:58 Longevity reframe: thriving with age... 01:06:46 Advice for early action... 01:07:09 Our Amazing Sponsors: Primeadine by Oxford Healthspan — A food-derived spermidine supplement that supports autophagy and cellular renewal without fasting, made from Japanese wheat germ with clean, rigorously tested ingredients (including a gluten-free option); visit oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout. Magnesium Breakthrough by BIOptimizers — A full-spectrum magnesium supplement combining seven highly absorbable forms to support sleep, stress, muscle recovery, and nervous system balance in one nightly habit. Save 15% at bioptimizers.com/bionat with code BIONAT Nature's Marvels Bioregulators - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to profound-health.com and use code NAT15 for 15% off your first order. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

Today, I'm joined by Erin Ryan, my producer and long-time collaborator, for a special Q&A episode powered entirely by your questions. After our bioregulator deep dive with Dr. Bill Lawrence, the response was overwhelming—so many of you reached out with insightful queries about bioregulators, peptides, and the nuances between natural and synthetic options. Erin and I decided to tackle the most common themes, unpacking everything from organ versus system signaling to how bioregulators actually survive digestion. Nat's favorite Bioregulators: Nature's Marvels Bioregulators and use code NAT15 for 15% off your first order. The Bioregulator Company and use code NAT10 for 10% off. Nanopep and click "shop" and use code NAT for 10% off. Episode Timestamps: Episode introduction and Q&A format... 00:00:00 Natural vs. synthetic bioregulators... 00:08:24 Peptide signaling and digestion... 00:11:35 Brand reliability and BPC-157 oral benefits... 00:20:18 Organ/system signaling basics... 00:25:42 Bioregulator priorities and cycle protocols... 00:29:51 Healthy, preventative, and age-related use... 00:38:44 Are organ meats enough? Food vs. supplements... 00:41:46 Clinical evidence and biggest impact... 00:47:57 Resilience, wrap-up, and sourcing info... 00:52:09 Our Amazing Sponsors: Ozlo - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to ozlosleep.com/nat and use code NAT to get $75 off. Vitali - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. O₃RACLE by Wizard Sciences — A daily ozonated oil capsule designed to support immune balance, cellular communication, and antioxidant production without clinics, machines, or complicated routines; learn more at wizardsciences.com and use code NAT15 for 15% off. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

Regina Druz, a cardiologist who reimagined heart health after years in elite academic medicine. Druz opens up about her journey from the traditional halls of Cornell and New York Presbyterian to creating truly personalized, preventive, and holistic programs for her patients—even when it meant leaving behind the medical mainstream. Episode Timestamps: Podcast intro and Dr. Druz's background... 00:00:00 The value of female perspectives in cardiology... 00:04:11 Moving from traditional to integrative cardiology... 00:13:17 Upsides of personalization vs. "fire and forget"... 00:22:15 Prevention through personalized genetics... 00:26:11 Population vs. individual risk and aging... 00:38:05 Impact of genetics and nutrition on heart health... 00:45:07 Healthcare's prevention gap... 00:48:38 Deeper causes: treating the "why," not just blocked arteries... 00:50:18 Screening earlier and understanding vascular age... 01:05:30 Epicardial fat, inflammation, and menopause's impact... 01:10:39 Wearables, AI, and the future of cardiology... 01:22:18 Heart-brain connection: stress, trauma, and longevity... 01:26:35 Our Amazing Sponsors: Cozy Earth – Thoughtfully designed bedding and bath essentials that turn your home into a calm, elevated retreat and actually hold up wash after wash. Give your space a reset at cozyearth.com with code LONGEVITY for up to 20% off, and don't forget to mention this podcast in the post-purchase survey. Magnesium Breakthrough by BIOptimizers — A full-spectrum magnesium supplement combining seven highly absorbable forms to support sleep, stress, muscle recovery, and nervous system balance in one nightly habit. Save 15% at bioptimizers.com/bionat with code BIONAT Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset after the holidays without suffering. Go to lvluphealth.com and use code NAT for 20% off. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

Clement Lee, a naturopathic doctor blending ancient wisdom from Chinese medicine with cutting-edge regenerative therapies. In this episode, Dr. Lee gets real about why people can feel deeply unwell long before anything shows up on standard labs—and how subtle issues like limbic system stress, toxins, and chronic inflammation quietly undermine our vitality. Episode Timestamps: Welcome and episode overview... 00:00:00 Prolotherapy, Chinese medicine, and complex healing cases... 00:05:16 Common misconceptions in chronic illness treatment... 00:13:15 Why mindset and the limbic system affect healing... 00:18:02 Early warning signs of chronic illness... 00:22:50 Evaluating toxins, hormones, and inflammation in root cause medicine... 00:26:03 Toxic overload concerns in children... 00:27:09 First steps for chronic, hard-to-treat cases... 00:31:56 Top interventions for longevity now... 00:33:43 Testing for heavy metals and toxins... 00:35:12 Inflammation loops and surprising causes like mold... 00:38:12 The role of cellular healing and the nervous system... 00:47:09 Advanced therapies: peptides, IV nutrients, and more... 00:52:01 Mast cell activation and immune overdrive signals... 01:08:23 Key takeaways and easy strategies for stress... 01:26:40 Our Amazing Sponsors: Mitopure Longevity Gummies by Timeline — Clinically backed Urolithin A supports mitochondrial health to boost energy, recovery, and healthy aging, all in an easy daily gummy instead of another pill; go to timeline.com/nat20 for 20% off Mitopure Gummies. BEAM Minerals - Low energy often starts in the mitochondria. Youth Daily by Young Goose — An all-in-one moisturizer powered by NAD+ nano precursors to boost elasticity, smooth wrinkles, and keep your skin looking fresh, dewy, and full of life; grab yours at younggoose.com and use code Nat10 for first orders or 5NAT for returning customers. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

Today, I've got a conversation that goes deep into the cutting edge of regenerative skin health with two exceptional guests: Debbi Barber, founder and muse of Vitali Skincare, and Dr. Jordan Plews, a biochemical engineer and stem cell researcher. We discuss the science and practical realities of exosomes, stem cells, and copper peptides—breaking down not just what makes skin look younger, but what truly keeps it biologically healthier and more resilient as we age. 00:00:00 Shift from beauty to science and health... 00:09:23 GHK-Cu's role in longevity and skin repair... 00:10:15 Dr. Plews on regenerative medicine and stem cells... 00:11:14 From peptides to exosomes: product evolution... 00:13:35 Stem cell exhaustion and need for exosome signaling... 00:14:07 Copper peptides vs. exosomes: complementary actions... 00:18:00 Why source and age of exosomes matter... 00:25:20 Quality, safety, and labeling in exosome products... 00:35:01 How exosomes and peptides benefit skin deeper layers... 00:44:35 Visible results: barrier, redness, scars, texture... 00:58:05 What to expect: younger vs. older skin... 01:00:01 Proof and stories: customer transformations... 01:01:59 More isn't better: exosome dosing myth... 01:07:03 Supporting ingredients: vitamin C, glutathione, SOD2... 01:11:31 Skin as a window into systemic aging... 01:19:08 The future: personalized, organ-targeted exosome therapies... 01:24:02 Our Amazing Sponsors: Nature's Marvels Bioregulators - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to profound-health.com and use code NAT15 for 15% off your first order. Manukora Honey - rich, creamy Manuka honey packed with powerful bioactives, all in just one heaped teaspoon a day. Go to MANUKORA.com/NAT to save up to 31% plus $25 in free gifts with the Starter Kit. PW1 by Puori — A clean, high-quality whey protein that's third-party tested for over 200 contaminants and smooth enough to feel like a treat while supporting muscle, metabolism, and bone strength. Go to puori.com/NAT and use code NAT for 32% off your first subscription or 20% off anything on the site. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

Stephen Hussey —a clinician, author of Understanding The Heart, and a powerful force in rethinking everything we thought we knew about heart disease. Dr. Hussey's own journey began with type 1 diabetes as a child, and despite living a healthy, active lifestyle, he experienced a widowmaker heart attack at just 34 years old. In our conversation, he opens up about what it was like to face this crisis with "perfect" lab numbers, how it challenged his entire perspective, and ultimately led him to a radical new understanding of heart health and longevity. Episode Timestamps: Podcast introduction and heart disease focus... 00:00:00 Dr. Stephen Hussey's health story and diabetes management... 00:04:16 Heart attack, hospital experience, and challenging cholesterol dogma... 00:15:04 How Dr. Hussey reversed arterial plaque... 00:21:47 Rethinking heart function: vortex vs. pump... 00:24:17 Structured water, hydration, and blood flow... 00:36:39 Sunlight, grounding, and circadian rhythm for heart health... 00:46:13 Impact of EMFs on blood and cellular energy... 01:01:03 Actionable strategies to future-proof your heart... 01:08:17 Trauma and emotional health in longevity... 01:10:14 Evaluating your healthcare team holistically... 01:12:28 Dr. Hussey's philosophy on nature and letting go... 01:21:05 Closing thoughts and how to find Dr. Hussey... 01:28:14 Our Amazing Sponsors: Cozy Earth by Cozy Earth – Thoughtfully designed bedding and bath essentials that turn your home into a calm, elevated retreat and actually hold up wash after wash. Give your space a reset at cozyearth.com with code LONGEVITY for up to 20% off, and don't forget to mention this podcast in the post-purchase survey. O₃RACLE™ by Wizard Sciences — A daily ozonated oil capsule designed to support immune balance, cellular communication, and antioxidant production without clinics, machines, or complicated routines; learn more at wizardsciences.com and use code NAT15 for 15% off. Vitali - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

Today, I'm joined by the wonderful Dr. Shivani Gupta, a true force in bridging ancient Ayurvedic wisdom with cutting-edge modern research on inflammation and healthy aging. She recently authored The Inflammation Code. Dr. Shivani opens up about her deeply personal motivation—from witnessing her grandfather's preventable health decline to spending years in both traditional and scientific studies, ultimately earning a PhD focused on turmeric and chronic inflammation. For Dr. Shivani's Turmeric and sleep gummies visit https://fusionaryformulas.com/?sca_ref=9671225.dtSyos3QQx1c and use code NAT15 for 15% off. Episode Timestamps: Welcome & Introduction to Longevity Podcast... 00:00:00 Autophagy & Spermidine Supplementation... 00:02:41 Personal Connection & Product Experience... 00:03:46 Health Declines in Modern Indian Culture... 00:07:47 Reversing Disease: Ayurveda & Biohacking... 00:11:11 Discovering Ayurveda & Turmeric's Power... 00:15:12 Turmeric vs. NSAIDs: Scientific Support... 00:19:52 PPIs, Gut Health, and Curcumin... 00:21:26 Inflammation as the Root of Chronic Disease... 00:23:24 Sleep Rituals & Circadian Timing... 00:28:59 Elemental Design / Doshas Explained... 00:32:13 Aligning Lifestyle with Dosha for Health... 00:42:46 Mental Inflammation: Stress & Burnout... 00:46:00 Turmeric Science, Uses & Myths... 00:54:20 Personalized Spice Use & Dosha Guidance... 01:03:48 Top Spices for Longevity... 01:07:44 Cautions: Medications & Turmeric... 01:10:03 The Future of Inflammation in Medicine... 01:11:11 Rapid-Fire Longevity Habits... 01:15:03 Our Amazing Sponsors: Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset without suffering. Go to lvluphealth.com and use code NAT for 20% off. Primeadine by Oxford Healthspan — A food-derived spermidine supplement that supports autophagy and cellular renewal without fasting, made from Japanese wheat germ with clean, rigorously tested ingredients (including a gluten-free option); visit oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout. Gut Essentials Bundle by Just Thrive — A powerful duo of a clinically proven probiotic and digestive bitters to reduce bloat, boost energy, curb cravings, and help you feel your best fast, backed by a 100% money-back guarantee — Take the Feel Better Challenge and save 20% at JustThriveHealth.com/NAT20 with promo code NAT20. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

Jeffrey Gladden —a trailblazer in longevity medicine who once spent decades as an interventional cardiologist, only to challenge everything he knew after his own health hit a wall. Dr. Gladden opens up about the moment he refused to accept "normal for your age" as a diagnosis, launching himself into the world of functional and age-management medicine to reclaim his vitality and help others do the same. Episode Timestamps: Welcome and episode introduction... 00:00:00 Health crisis and discovering personal optimization... 00:07:05 From "sick care" to health optimization... 00:10:46 Vision for personalized, youthful longevity... 00:12:17 Personalized medicine: why one size doesn't fit all... 00:16:00 Linear versus exponential aging; fixing a flawed approach... 00:18:02 Five circles of exponential health: key longevity domains... 00:19:23 Curiosity, growth mindset, and quantum thinking in longevity... 00:22:22 Why individualization is crucial for diet and interventions... 00:28:52 Insulin resistance: the hidden driver of aging... 00:33:41 Environmental and internal (psychospiritual) factors in health... 00:38:40 Healing through meditation, stress management, and flow... 00:41:15 Robustness, resilience, and anti-fragility as longevity superpowers... 00:57:09 Safe, personalized hormone therapy and the importance of tracking... 01:03:33 Integrating mindset, purpose, and psycho-spiritual work... 01:08:50 Peptides and advanced therapies: preparing for optimal results... 01:09:56 Common test misconceptions in longevity medicine... 01:12:56 Debunking the myth of single biological age... 01:16:38 Resources, connect with Dr. Gladden, and closing... 01:18:09 Our Amazing Sponsors: Youth Daily by Young Goose — An all-in-one moisturizer powered by NAD+ nano precursors to boost elasticity, smooth wrinkles, and keep your skin looking fresh, dewy, and full of life; grab yours at younggoose.com and use code Nat10 for first orders or 5NAT for returning customers. Quantum Upgrade - Supports nervous system balance without wearables or apps—just effortless, 24/7 quantum energy streaming. With 21+ studies showing measurable improvements in stress and cellular function, it's easy to try for yourself. Mitopure®️ Longevity Gummies by Timeline — Clinically backed Urolithin A supports mitochondrial health to boost energy, recovery, and healthy aging, all in an easy daily gummy instead of another pill; go to timeline.com/nat20 for 20% off Mitopure®️ Gummies. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

Gus Vickery, a good friend and one of my favorite collaborators when it comes to cutting-edge insights in personalized health and longevity. In this episode, I put myself under the microscope as we walk through my own metabolomics testing after a period of heavy travel, stress, and—yes—a break from my usual supplement routine. If you've ever wondered whether skipping your foundational health habits "just for a little while" really matters, you're about to find out. If you are a clinician and would like to offer the Aristotle test to your patients please use this link to learn more about the Theriome test: therio.me/niddam If you are a patient and would like to run the Theriome Aristotle test and get a full interpretation and protocol based on your results from Dr Vickery & his team please use this link: https://authentichealth.com/precision-health-evaluation/ Episode Timestamps: Introduction to Longevity Podcast and episode overview... 00:00:00 Metabolomics and interpreting health data – practitioner guidance needed... 00:05:05 Combining metabolomics, gut, and blood data for whole-system insights... 00:06:02 Nutrient depletion and oxidative stress: critical findings... 00:18:57 Supplementation essentials for aging well... 00:27:05 Metabolomics comparison by age group and optimization goals... 00:29:03 Stacking interventions: why less is more with diagnostics... 00:31:05 Functional health markers and the value of context... 00:34:47 Sympathetic dominance, mindset, and impact on longevity... 00:35:26 Restoring nervous system balance – inner work and tech tools... 00:42:38 Toxins, heavy metals, and practical detox strategies... 00:49:11 Clean environment, resiliency, and realistic lifestyle shifts... 00:55:29 Key nutrient deficiencies revealed by metabolomics... 01:09:15 Genetic and metabolomic tests: what's actionable?... 01:15:07 Hope for the future: human resilience and expanding technology... 01:22:24 Weekly actionable: walk outside for mitochondria and stress relief... 01:26:55 Our Amazing Sponsors: Cozy Earth – Thoughtfully designed bedding and bath essentials that turn your home into a calm, elevated retreat and actually hold up wash after wash. Give your space a reset at cozyearth.com with code LONGEVITY for up to 20% off, and don't forget to mention this podcast in the post-purchase survey. Nature's Marvels Bioregulators - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to profound-health.com and use code NAT15 for 15% off your first order. Blue Peptide Spray from Young Goose brings the message back loud and clear. With NAD+ APEX to refuel energy, methylene blue to recharge your mitochondria, and GHK-Cu to tell your skin, "Hey, start making that collagen again!" It's longevity science, not cosmetic hype. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

Gabrielle Lyon, a pioneer in redefining the longevity conversation by making muscle health—not weight—the centerpiece of aging well. With a background in geriatrics and nutritional sciences, she illuminates why the quality of your muscle tissue is a far more powerful predictor of health than any number on the scale. Her perspective challenges the notion of a "healthy sedentary person" and reveals the major role of intramuscular fat in metabolic dysfunction. Episode Timestamps: Introduction, podcast focus, and welcoming Dr. Gabrielle Lyon... 00:00:00 Muscle's impact on brain health, inflammation, and healthy aging... 00:01:03 Dr. Lyon's childhood, grit, and self-discipline... 00:04:33 Mentorship and protein science under Dr. Donald Lehman... 00:07:05 Muscle as the overlooked metabolic organ... 00:08:45 Why intramuscular fat matters more than body weight... 00:10:06 Plant vs. animal protein for muscle health... 00:13:29 Muscle as an endocrine organ and cognition... 00:16:21 Future of muscle science: anabolics, imaging, and technology... 00:18:22 GLP-1s, sarcopenic obesity, and muscle-first protocol... 00:46:45 Sarcopenia, aging, and the importance of early training... 01:04:35 Building lifelong resilience—mental and physical... 01:08:31 Predictions: anabolics, muscle testing, and assessment... 01:12:17 "Strength is a responsibility, not a luxury"... 01:13:53 Our Amazing Sponsors: Cozy Earth – Thoughtfully designed bedding and bath essentials that turn your home into a calm, elevated retreat and actually hold up wash after wash. Give your space a reset at cozyearth.com with code LONGEVITY for up to 20% off, and don't forget to mention this podcast in the post-purchase survey. Ozlo - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to ozlosleep.com/nat and use code NAT to get $75 off. Tranq Dart by Wizard Sciences - a multi-pathway sleep support from Wizard Sciences. It's not a knockout pill; it's a gentle nudge toward that wind-down zone. I take it about 30 minutes before bed, and it helps my body and brain sync up for sleep. Sleep smarter, not harder. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

Today, I'm joined by the incredible Anthony Castore, a trailblazer who fuses elite strength coaching with deep cellular medicine. In our conversation, Anthony shares his journey from a young athlete determined to defy genetic odds to becoming an expert in both physical training and the nuanced science of peptides, mitochondria, and bioregulators. Use code NAT10 for 10% off products at https://alchemiqlabs.com/ Episode Timestamps: Welcome and episode introduction... 00:00:00 Anthony Castore's path from strength coaching to cellular medicine... 00:05:55 Connecting strength training with cellular pathways (AMPK, mTOR)... 00:12:27 Explaining and balancing AMPK and mTOR for performance... 00:13:03 Training strategies: Metabolic, hypertrophy, and neural approaches... 00:18:18 Building a solid foundation: Lifestyle, training, nutrition, peptides... 00:23:04 Assessing recovery capacity and individualizing protocols... 00:26:02 Mitochondrial fission, fusion, and targeted adaptation... 00:29:57 Optimizing muscle gain and fat loss through calories and recovery... 00:31:00 Differentiating bodybuilder vs. longevity approaches... 00:34:44 Integrating peptides and support molecules into routines... 00:40:44 Ketone esters and mitochondrial peptide interventions... 00:41:20 Cautions on stacking and combining interventions... 00:54:04 Lessons learned from overdoing interventions... 01:05:02 Our Amazing Sponsors: Vitali - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. BEAM Minerals - Low energy often starts in the mitochondria. Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset after the holidays without suffering. Go to lvluphealth.com and use code NAT for 20% off. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

Today, I'm joined by the deeply thoughtful and refreshingly honest Dr. Sanjay Bhojraj, a self-described "curious cardiologist" who spent decades treating heart attacks in the cath lab — before stepping away to ask a bigger question: Why are we waiting for the crisis instead of preventing it? Episode Timestamps: Welcome to Longevity & episode setup … 00:00:00 Dr. Bhojraj's shift from ER cardiology to prevention … 00:06:30 Why most heart attacks aren't caused by big blockages … 00:09:15 Stress, nervous system load & heart attack risk … 00:13:10 CIMT explained: what it measures (and what it misses) … 00:26:40 Calcium scores vs CT angiograms … 00:35:45 CLEERLY scan: seeing dangerous soft plaque … 00:38:45 Can plaque actually regress? … 00:41:55 When heart scans make patients less afraid … 00:44:05 When should you test — even without symptoms? … 00:45:50 Why age 45 is a major cardiovascular inflection point … 00:47:10 Hormones, estrogen loss & women's heart risk … 00:50:10 Why cardiology still misunderstands women … 00:54:30 Small dense LDL, ApoB & oxidized cholesterol … 01:02:00 Why fixing inflammation matters more than numbers … 01:05:50 Our Amazing Sponsors: Regenerive - Built around clinically validated Longufera (Ash X4) to support core aging pathways—so it's not just "healthy aging" in theory. Go to regenerive.co and use code NAT25 to save 25% Mitopure® Longevity Gummies are the only clinically proven Urolithin A gummies supporting mitochondrial health — one of the key hallmarks of aging. PW1 by Puori — A clean, high-quality whey protein that's third-party tested for over 200 contaminants and smooth enough to feel like a treat while supporting muscle, metabolism, and bone strength. Go to puori.com/NAT and use code NAT for 32% off your first subscription or 20% off anything on the site. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

Today, I'm joined by Charles Bohdy, a true innovator in water purification technology, and Victor Sagalovsky, a passionate advocate for bringing the science of water quality into our daily lives. Together, we take a deep dive into the unseen world of the water running through our homes—exploring not just its purity, but its hidden potential to support our biology in ways most of us have never considered. Whole HOME Water System - Use code NAT100 Episode Timestamps: Intro to Longevity Podcast and today's water focus... 00:00:00 Water system's health benefits and testing... 00:01:33 Why water quality is overlooked yet critical... 00:07:20 Common water issues and municipal limitations... 00:09:10 Filtration methods: carbon blocks and pathogens... 00:15:26 Charles's nano-ceramic multilayer filters... 00:20:14 Concerns with chlorine and fluoride in water... 00:23:44 Retaining healthy minerals: charge-based filtration... 00:35:18 Reverse osmosis: pros, cons, and fungal risks... 00:50:49 Structured water's role in biological health... 00:56:53 Water structuring: agricultural validation... 01:00:21 Whole-home filtration: installation and costs... 01:11:02 Closing thoughts: bringing nature's water home... 01:25:00 Our Amazing Sponsors: Regenerive - Built around clinically validated Longufera (Ash X4) to support core aging pathways—so it's not just "healthy aging" in theory. Go to regenerive.co and use code NAT25 to save 25% Primeadine by Oxford Healthspan: Primeadine supports autophagy — your cells' natural renewal and cleanup process — using food-derived spermidine, no fasting required. If you want to support resilience from the inside out, head to https://www.oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout (one-time purchases only). Ozlo - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to ozlosleep.com/nat and use code NAT to get $75 off. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

Mass Spec —an academic analytical chemist from UC Irvine whose mission is to uncover what's really in our everyday foods, drinks, and products. Ben reverse engineers everything from Taco Bell meat to Doritos, and sometimes even entire industries, using cutting-edge mass spectrometry. His curiosity and expertise have made him a go-to source for those wanting to know what's hiding behind vague ingredient labels and "natural flavors." Episode Timestamps: Welcome and podcast introduction... 00:00:00 What is mass spectrometry?... 00:05:00 Viral "what's in it?" projects and public interest... 00:07:27 Synthetic vs. plant-derived nicotine and toxins in plant extracts... 00:09:53 Food label transparency and loopholes (natural flavors, FEMA, GRAS)... 00:20:11 Sweeteners & artificial additives: sucralose, stevia, cost motivations... 00:23:07 Ultra pasteurization of milk and added flavors... 00:29:48 Chocolate, caffeine content, and labeling challenges... 00:33:12 Industrial food processes, GMOs, and food security insights... 00:38:36 Microplastics: occurrence, regulation, and PEG in food... 00:50:15 Supplements under development for microplastic removal... 00:58:43 Adulteration in olive oil, maple syrup, and honey... 01:04:08 Hidden sweeteners, and processed food pitfalls... 01:10:14 Avoid artificial sweeteners, problematic plastics, and hidden flavors... 01:14:36 Our Amazing Sponsors: Manukora Honey - rich, creamy Manuka honey packed with powerful bioactives, all in just one heaped teaspoon a day. Go to MANUKORA.com/NAT to save up to 31% plus $25 in free gifts with the Starter Kit. Magnesium Breakthrough - uses seven absorbable forms of magnesium to support deeper sleep, calmer nerves, and real recovery. Nature's Marvels Bioregulators - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to profound-health.com and use code NAT15 for 15% off your first order. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

Today, I'm kicking off the new year with a back-to-basics deep dive into one of the most pivotal yet overlooked foundations of longevity: gut health. Over the past episodes, we've explored everything from gene therapy to advanced tech, but it all comes back to the habits and systems we rely on every single day—and the gut is right at the center of that equation. Episode Timestamps: Gut health as the cornerstone of longevity... 00:00:00 Why disease and wellness begin in the gut... 00:03:46 Symptoms and signs of gut imbalance... 00:08:53 Normalizing digestive discomfort... 00:09:33 Key stressors for gut health: stress, poor food choices... 00:12:03 How chronic stress disrupts digestion... 00:12:59 Processed foods, toxins, and nutrient deficiencies... 00:13:14 The importance of whole foods, healthy fats, and cooked veggies... 00:14:27 Testing and understanding your own food tolerances... 00:16:31 Risks of dehydration, overtraining, and PPIs... 00:19:24 Structure of a healthy gut: digestion, gut barrier, organ support... 00:23:19 Pre-meal rituals for better digestion... 00:25:33 Choosing and introducing probiotics and fiber... 00:37:44 Tracking your food and gut motility... 00:42:12 Lifestyle habits: exercise, sleep, stress, meal timing... 00:45:00 Avoiding snacking and late meals... 00:49:05 Remove offenders, restore with enzymes, replenish with probiotics... 00:50:12 Bone broth, anti-inflammatory foods, and gut repair... 00:54:19 Peptides and bioregulators for organ optimization... 00:57:03 Our Amazing Sponsors: Tranq Dart by Wizard Sciences - a multi-pathway sleep support from Wizard Sciences. It's not a knockout pill; it's a gentle nudge toward that wind-down zone. I take it about 30 minutes before bed, and it helps my body and brain sync up for sleep. Sleep smarter, not harder. Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset after the holidays without suffering. Go to lvluphealth.com and use code NAT for 20% off. Vitali - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group